1-Pentanethiol → 1-(Diphenylmethyl)-3-(pentylthio)azetidine

HRID 82961

反応式

HRID 82961 の反応式
[CH2:1]([SH:6])[CH2:2][CH2:3][CH2:4][CH3:5].[H-].[Na+].CS(O[CH:14]1[CH2:17][N:16]([CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:15]1)(=O)=O.C([O-])(O)=O.[Na+]>CS(C)=O>[C:19]1([CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:16]2[CH2:17][CH:14]([S:6][CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH2:15]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

参加物

6

反応物 4

HCID 80671-PentanethiolHCID 24758Sodium hydrideHCID 516892Sodium BicarbonateHCID 27587161-(Diphenylmethyl)azetidin-3-yl methanesulfonate

生成物 1

HCID 671546441-(Diphenylmethyl)-3-(pentylthio)azetidine収率 96%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
0 °C

実験手順

To a solution of pentanethiol (248 μL, 2.0 mmol) in DMSO (2.5 mL) at 0° C. under nitrogen was added NaH (60% in oil, 80 mg, 2.0 mmol). The suspension was stirred for 0.5 h at 0° C. then treated with 1-(diphenylmethyl)azetidin-3-yl methanesulfonate (317 mg, 1.0 mmol; which may be prepared as described in Step 1) and the mixture allowed to warm to room temperature overnight. Saturated NaHCO3 (5 mL) was added and the mixture was extracted with diethyl ether. The organic layer was separated from the aqueous and the organic washed with brine, dried over Na2SO4 and concentrated to give the product (312 mg, 96%) as a yellow oil.

後処理

  1. temperatureto warm to room temperature overnight
  2. extractionthe mixture was extracted with diethyl ether
  3. customThe organic layer was separated from the aqueous and the
  4. washorganic washed with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-9db5e2616292487cb7e0fd504a634062
出典データセット
uspto-grants-2014_09
特許番号
US08846711B2

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