Water → HCID 52950664、化合物

HRID 83020ノート

反応式

HRID 83020 の反応式
[OH-].[Na+:2].[O:3]=[C:4]1[NH:9][C:8]2[N:10]=[CH:11][C:12](/[CH:14]=[CH:15]/[C:16](=[O:28])[N:17]3[CH2:20][CH:19]([O:21][CH2:22][C:23]4[S:24][CH:25]=[CH:26][CH:27]=4)[CH2:18]3)=[CH:13][C:7]=2[CH2:6][N:5]1[CH2:29][C:30]([O:32]CC)=[O:31].O>CO>[O:3]=[C:4]1[NH:9][C:8]2[N:10]=[CH:11][C:12](/[CH:14]=[CH:15]/[C:16](=[O:28])[N:17]3[CH2:20][CH:19]([O:21][CH2:22][C:23]4[S:24][CH:25]=[CH:26][CH:27]=4)[CH2:18]3)=[CH:13][C:7]=2[CH2:6][N:5]1[CH2:29][C:30]([O-:32])=[O:31].[Na+:2]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 68338152(E)-Ethyl 2-(2-oxo-6-(3-oxo-3-(3-(thiophen-2-ylmethoxy)azetidin-1-yl)prop-1-enyl)-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)acetate

生成物 1

HCID 52950664HCID 52950664、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of sodium hydroxide (1N, 438 μL, 0.44 mmol) was added to a suspension of (E)-ethyl 2-(2-oxo-6-(3-oxo-3-(3-(thiophen-2-ylmethoxy)azetidin-1-yl)prop-1-enyl)-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)acetate (100 mg, 0.22 mmol) in methanol (5 mL) at room temperature. The reaction mixture was refluxed for 15 minutes then poured into cold water. The resulting precipitate was filtered and washed with diethyl ether. The title product was obtained as a white solid (53.5 mg, 54%).

後処理

  1. temperatureThe reaction mixture was refluxed for 15 minutes
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-33b201f5a01b498eadf45c09e2a1cfbc
出典データセット
uspto-grants-2014_09
特許番号
US08846711B2

反応ノート

読み込み中…