2,4-Difluorobenzenesulfonyl Chloride → 1-[(2,4-Difluorophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride

HRID 8321

反応式

HRID 8321 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[CH:17][NH:18]3)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[F:23][C:24]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=1[S:31]([Cl:34])(=[O:33])=[O:32]>>[ClH:34].[F:23][C:24]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=1[S:31]([N:18]1[C:19]2[C:15](=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:22]=[CH:21][CH:20]=2)[CH:16]=[CH:17]1)(=[O:33])=[O:32]

参加物

3

反応物 2

HCID 27342732,4-Difluorobenzenesulfonyl ChlorideHCID 22015386tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate

生成物 1

HCID 102018281-[(2,4-Difluorophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride

実験手順

The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 2,4-di-fluorophenylsulfonylchloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.41 (br, 1 H), 8.24 (m, 1 H), 7.75 (m, 1 H), 7.58 (m, 1 H), 7.47–7.33 (m, 2 H), 7.23 (t, J=8 Hz, 1 H), 6.99 (d, J=5 Hz, 1 H), 6.70 (d, J -8 Hz, 1 H), 3.25 (m, 8 H). MS (ESI+) for m/z 378 (M+H)+.

出典と根拠

ORDレコード
ord-d86cc93f907f48b381a9d7bc63bf7406
出典データセット
uspto-grants-2006_08
特許番号
US07087750B2

関連ノート

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