Chlorosuccinimide → 4-Fluoro-N-hydroxybenzimidoyl chloride

HRID 83421

反応式

HRID 83421 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5](/[CH:6]=[N:7]\[OH:8])=[CH:4][CH:3]=1.[Cl:11]N1C(=O)CCC1=O>CN(C=O)C>[OH:8]/[N:7]=[C:6](\[Cl:11])/[C:5]1[CH:9]=[CH:10][C:2]([F:1])=[CH:3][CH:4]=1

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 5372466Benzaldehyde, p-fluoro-, oxime

生成物 1

HCID 57063604-Fluoro-N-hydroxybenzimidoyl chloride収率 100.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of (E)- and/or (Z)-4-fluoro-benzaldehyde oxime (100 g, 719 mmol) in DMF (500 mL) was added N-chlorosuccinimide (110 g, 791 mmol) portionwise keeping the temperature below 70° C. The reaction mixture was stirred at room temperature for 2.5 h and then extracted with tert-butyl methyl ether to afford the title compound (125 g, 100%) which was obtained as a yellow oil. MS: m/e=173.1 [M]+.

後処理

  1. customthe temperature below 70° C
  2. extractionextracted with tert-butyl methyl ether

出典と根拠

ORDレコード
ord-3e0b07dfc2d0475b8709a2e52fbf575e
出典データセット
uspto-grants-2014_09
特許番号
US08846719B2

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