L-Alaninol → 6-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-n-((s)-2-hydroxy-1-methyl-ethyl)-nicotinamide

HRID 83429

反応式

HRID 83429 の反応式
CO[C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[C:13]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)=[N:14][O:15][CH:16]=2)=[N:6][CH:5]=1.[CH3:25][C@H:26]([NH2:29])[CH2:27][OH:28]>>[F:23][C:20]1[CH:19]=[CH:18][C:17]([C:13]2[C:12]([CH2:11][O:10][C:7]3[CH:8]=[CH:9][C:4]([C:3]([NH:29][C@@H:26]([CH3:25])[CH2:27][OH:28])=[O:24])=[CH:5][N:6]=3)=[CH:16][O:15][N:14]=2)=[CH:22][CH:21]=1

参加物

3

反応物 2

HCID 80307L-AlaninolHCID 684439776-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

生成物 1

HCID 426305446-[3-(4-Fluoro-phenyl)-isoxazol-4-ylmethoxy]-n-((s)-2-hydroxy-1-methyl-ethyl)-nicotinamide収率 59%

実験手順

As described for example 325, 6-[3-(4-fluoro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (60 mg, 0.18 mmol) was converted, using S-(+)-2-amino-1-propanol instead of rac-2-amino-1-propanol, to the title compound (28 mg, 59%) which was obtained as a white solid MS: m/e=370.3 [M−H]−.

出典と根拠

ORDレコード
ord-86eee24f569d49758388980083c50d8d
出典データセット
uspto-grants-2014_09
特許番号
US08846719B2

関連ノート

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