Anisole → 5-Oxopyrrolidine-3-carboxylic acid

HRID 83505ノート

反応式

HRID 83505 の反応式
COC1C=C(OC)C=CC=1C[N:6]1[C:10](=[O:11])[CH2:9][CH:8]([C:12]([OH:14])=[O:13])[CH2:7]1.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[O:11]=[C:10]1[NH:6][CH2:7][CH:8]([C:12]([OH:14])=[O:13])[CH2:9]1

参加物

4

反応物 2

HCID 7519AnisoleHCID 112544611-(2,4-Dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid

生成物 1

HCID 167851365-Oxopyrrolidine-3-carboxylic acid収率 75%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

反応条件

温度
80 °C

実験手順

To an optically active compound of 1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid (14.3 g) were added anisole (8.4 ml) and trifluoroacetic acid (100 ml), and the mixture was stirred at 80° C. for 5 hours. This reaction solution was cooled to room temperature, and concentrated under reduced pressure. To the resulting residue was added diisopropyl ether (100 ml), and the mixture was stirred at room temperature. The insoluble substance was collected by filtration, washed with diisopropyl ether, and dried under reduced pressure to give the titled compound (4.96 g).

後処理

  1. temperatureThis reaction solution was cooled to room temperature
  2. concentrationconcentrated under reduced pressure
  3. additionTo the resulting residue was added diisopropyl ether (100 ml)
  4. stirringthe mixture was stirred at room temperature
  5. filtrationThe insoluble substance was collected by filtration
  6. washwashed with diisopropyl ether
  7. customdried under reduced pressure

出典と根拠

ORDレコード
ord-3902df9d1e3f4dd193d45df2dbdae501
出典データセット
uspto-grants-2014_09
特許番号
US08846746B2

反応ノート

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