HCID 86680359、化合物 → (R)-3-Methyl-2-oxoimidazolidine-4-carboxylic Acid tert-butyl Ester

HRID 83518ノート

反応式

HRID 83518 の反応式
[C:1]([O:5][C:6]([C@H:8]1[CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[C:10](=[O:23])[N:9]1[CH3:24])=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:5][C:6]([C@H:8]1[CH2:12][NH:11][C:10](=[O:23])[N:9]1[CH3:24])=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 86680359HCID 86680359、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 86680358(R)-3-Methyl-2-oxoimidazolidine-4-carboxylic Acid tert-butyl Ester収率 94%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of (R)-3-methyl-2-oxoimidazolidine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester (167 mg) in methanol (1.7 ml) was added 10 wt % palladium on carbon at room temperature, and the mixture was stirred for 15 hours under one atom. of hydrogen. Under nitrogen atmosphere, this reaction solution was filtered through Celite, and eluted with methanol. The filtrate was concentrated under reduced pressure to give the titled compound (94 mg).

後処理

  1. filtrationUnder nitrogen atmosphere, this reaction solution was filtered through Celite
  2. washeluted with methanol
  3. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-0eb9d5403b344898ad5f9e392dd915fa
出典データセット
uspto-grants-2014_09
特許番号
US08846746B2

反応ノート

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