(4R)-3-[(Benzyloxy)carbonyl]-2-oxoimidazolidine-4-carboxylic acid → (4R)-2-oxoimidazolidine-4-carboxylic acid

HRID 83549ノート

反応式

HRID 83549 の反応式
C(OC([N:11]1[C@@H:15]([C:16]([OH:18])=[O:17])[CH2:14][NH:13][C:12]1=[O:19])=O)C1C=CC=CC=1.[H][H]>CO.O1CCCC1.[Pd]>[O:19]=[C:12]1[NH:11][C@@H:15]([C:16]([OH:18])=[O:17])[CH2:14][NH:13]1

参加物

5

反応物 2

HCID 688195(4R)-3-[(Benzyloxy)carbonyl]-2-oxoimidazolidine-4-carboxylic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 7003745(4R)-2-oxoimidazolidine-4-carboxylic acid収率 71.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

Under nitrogen atmosphere, to a solution of (R)-2-oxoimidazolidine-1,5-dicarboxylic acid 1-benzyl ester (1.61 g) in methanol/tetrahydrofuran (4/1, 20 ml) was added 10 wt % palladium on carbon (161 mg) at room temperature, and the mixture was stirred for 24 hours under one atmosphere of hydrogen. Under nitrogen atmosphere, palladium on carbon in this reaction solution was filtered off through Celite, and the filtrate was concentrated under reduced pressure. To the resulting residue were added diisopropyl ether and n-hexane, and the mixture was stirred. A solid was collected from this suspension by filtration, and dried under reduced pressure to give the titled compound (565 mg).

後処理

  1. filtrationUnder nitrogen atmosphere, palladium on carbon in this reaction solution was filtered off through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. additionTo the resulting residue were added diisopropyl ether and n-hexane
  4. filtrationA solid was collected from this suspension by filtration
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-1a00e101946843eba1f536e4a40960ca
出典データセット
uspto-grants-2014_09
特許番号
US08846746B2

反応ノート

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