Trifluoroacetic acid → HCID 86680395、化合物

HRID 83587ノート

反応式

HRID 83587 の反応式
COC1C=C(OC)C=CC=1C[N:6]1[CH2:12][CH:11]([C:13]([OH:15])=[O:14])[C:8]2([CH2:10][CH2:9]2)[C:7]1=[O:16].C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>>[O:16]=[C:7]1[NH:6][CH2:12][CH:11]([C:13]([OH:15])=[O:14])[C:8]21[CH2:9][CH2:10]2

参加物

4

反応物 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 866803935-(2,4-Dimethoxybenzyl)-4-oxo-5-azaspiro[2.4]heptane-7-carboxylic Acid

生成物 1

HCID 86680395HCID 86680395、化合物収率 76.2%

反応条件

温度
80 °C

実験手順

To an optically active compound of 5-(2,4-dimethoxybenzyl)-4-oxo-5-azaspiro[2.4]heptane-7-carboxylic acid (372 mg) were sequentially added anisole (159 μl) and trifluoroacetic acid (5.6 ml) at room temperature, and the mixture was stirred at 80° C. for 4 hours. This reaction mixture was concentrated under reduced pressure, and diisopropyl ether (10 ml) was added thereto. The precipitated solid was collected by filtration to give the titled compound (144 mg).

後処理

  1. customat room temperature
  2. concentrationThis reaction mixture was concentrated under reduced pressure, and diisopropyl ether (10 ml)
  3. additionwas added
  4. filtrationThe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-a82509e990c64154b0a3ed9534001621
出典データセット
uspto-grants-2014_09
特許番号
US08846746B2

反応ノート

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