Hydrochloric Acid → 1-[(4-Chlorophenyl)methyl]-1H-imidazole-2-carboxylic acid

HRID 83659ノート

反応式

HRID 83659 の反応式
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][N:9]=[C:8]2[C:12]([O:14]CC)=[O:13])=[CH:4][CH:3]=1.[OH-].[Na+].O.Cl>CCO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][N:9]=[C:8]2[C:12]([OH:14])=[O:13])=[CH:17][CH:18]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68379775ethyl 1-(4-chlorobenzyl)-1H-imidazole-2-carboxylate

生成物 1

HCID 683797411-[(4-Chlorophenyl)methyl]-1H-imidazole-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 1-(4-chlorobenzyl)-1H-imidazole-2-carboxylate (7.28 g, 27.5 mmol), was dissolved in EtOH (10 mL) and 10% aq. NaOH (20 mL) and stirred at rt for 15 h. The solvent was then stripped off, water was added, and the solution acidified with HCl. The resulting precipitate was collected over a filter and washed with 1M HCl and dried to afford the title compound as a white powder without further characterization. (Yield: 6.506 g, 27.5 mmol, 100%)

後処理

  1. customThe resulting precipitate was collected over
  2. filtrationa filter
  3. washwashed with 1M HCl
  4. customdried

出典と根拠

ORDレコード
ord-a420a9d85db14e7db51511543c07ec47
出典データセット
uspto-grants-2014_09
特許番号
US08846684B2

反応ノート

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