Hydrochloric Acid → 1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylic acid

HRID 83683ノート

反応式

HRID 83683 の反応式
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([CH3:16])=[C:8]2[C:17]([O:19]CC)=[O:18])=[CH:4][CH:3]=1.[OH-].[Na+].O.Cl>CCO>[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([CH3:16])=[C:8]2[C:17]([OH:19])=[O:18])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68380183ethyl 1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylate

生成物 1

HCID 683797421-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

ethyl 1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylate (480 mg, 1.46 mmol) was dissolved in EtOH (15 mL) and 10% aq. NaOH was added (6 mL). The reaction was allowed to stir at rt for 32 h, at which time as much solvent was stripped off as possible, water was added, and the mixture cooled in an ice bath. The mixture was acidified with concentrated HCl and the precipitate collected over a filter. The title compound was obtained as a white powder that was not purified or characterized further. (Yield: 430 mg, 1.435 mmol, 98%)

後処理

  1. additionwas added
  2. temperaturethe mixture cooled in an ice bath
  3. customthe precipitate collected over a filter

出典と根拠

ORDレコード
ord-3b5ed9349d8747cb9ec225d9d34ca73a
出典データセット
uspto-grants-2014_09
特許番号
US08846684B2

反応ノート

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