Methyl iodide → Oxoglaucine methiodide

HRID 838930ノート

反応式

HRID 838930 の反応式
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[C:11]2[C:15]3[C:20]([C:21](=[O:22])[C:9]4=[C:10]2[C:5](=[CH:6][CH:7]=[N:8]4)[CH:4]=1)=[CH:19][C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3.[I:27][CH3:28]>CC(C)=O>[CH3:28][N+:8]1[CH:7]=[CH:6][C:5]2[C:10]3=[C:11]([C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=2)[C:15]2[C:20]([C:21](=[O:22])[C:9]=13)=[CH:19][C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=2.[I-:27]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 97662Oxoglaucine2 回

生成物 1

HCID 41680Oxoglaucine methiodide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Oxoglaucine methiodide was prepared from oxoglaucine in accordance with the process of Example V. A 31 mg sample of oxoglaucine was refluxed in 8 ml of acetone until it completely dissolved (approximately 30 minutes) and then 0.75 ml of iodomethane was added. The solution was refluxed until it became brown. The crystals were then collected by filtration to yield 15 mg of the methiodide salt, mp 255 d.

後処理

  1. dissolutioncompletely dissolved (approximately 30 minutes)
  2. temperatureThe solution was refluxed until it
  3. filtrationThe crystals were then collected by filtration

出典と根拠

ORDレコード
ord-b882f16c4ef2405baf31e5f047788dca
出典データセット
uspto-grants-1978_06
特許番号
US04093717

反応ノート

読み込み中…