Ammonium Hydroxide → 3,5-Difluorobenzenesulfonamide
反応式
[F:1][C:2]1[CH:3]=[C:4]([S:9](Cl)(=[O:11])=[O:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH4+:13].[OH-]>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:13])(=[O:11])=[O:10])[CH:5]=[C:6]([F:8])[CH:7]=1参加物
4
実験手順
To a solution of 3,5-difluorobenzenesulfonyl chloride (25 g, 0.117 mol) in THF (150 mL) was added 35% aq. NH4OH (120 mL) over 1 h in an ice-bath. After the reaction was complete, it was evaporated in vacuo. To a solution of this residue in water (150 mL) was added 2N HCl (1 mL). After stirring 1 h, the reaction mixture was filtered and dried under high vacuum to give 3,5-difluorobenzenesulfonamide as a light brown solid (19.9 g, 88%). 1H NMR (400 MHz, CDCl3) δ 7.49-7.44 (m, 2H), 7.04-6.99 (m, 2H).
後処理
- customit was evaporated in vacuo
- additionTo a solution of this residue in water (150 mL) was added 2N HCl (1 mL)
- filtrationthe reaction mixture was filtered
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-41a2ed1b02ef47148905575ab7720070
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846739B2
反応ノート
読み込み中…