Hydroxyamine hydrochloride → HCID 178526569、化合物

HRID 839206ノート

反応式

HRID 839206 の反応式
[N+:1]([C:4]1[O:8][C:7]([C:9]2[C:13]([CH:14]=O)=[CH:12][NH:11][N:10]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.[NH2:17][OH:18].C([O-])(=O)C.[Na+]>O>[N+:1]([C:4]1[O:8][C:7]([C:9]2[C:13]([CH:14]=[N:17][OH:18])=[CH:12][NH:11][N:10]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 1785198815-(5-nitrofuran-2-yl)-1H-pyrazole-4-carbaldehyde

生成物 1

HCID 178526569HCID 178526569、化合物収率 97%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

Stir together 18 g of 3-(5-nitro-2-furyl)-1H-pyrazole-4-carboxaldehyde, 6.95 of hydroxylamine hydrochloride and 8.2 g of sodium acetate in 70 ml of water for 1.5 hours at 70° C. Cool the resulting admixture slowly to 0° C. Separate the formed precipitate by vacuum filtration and wash the residue with several portions of ice-cold water to obtain a 97% yield of 3-(5-nitro-2-furyl)-1H-pyrazole-4-carboxaldehydeoxime [m.p. 233° to 235° C (with decomposition)].

後処理

  1. customSeparate the formed precipitate
  2. filtrationby vacuum filtration
  3. washwash the residue with several portions of ice-cold water

出典と根拠

ORDレコード
ord-340929421f6f44e6b481b3bbed7f15e4
出典データセット
uspto-grants-1978_06
特許番号
US04093812

反応ノート

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