Sodium Hydroxide → 3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carbonitrile

HRID 839224

反応式

HRID 839224 の反応式
[N+:1]([C:4]1[O:8][C:7]([C:9]2[C:13]([C:14]([NH2:16])=O)=[CH:12][N:11]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:10]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].P(Cl)(Cl)(Cl)=O.[OH-].[Na+]>ClCCCl>[N+:1]([C:4]1[O:8][C:7]([C:9]2[C:13]([C:14]#[N:16])=[CH:12][N:11]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:10]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 203261233-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carboxamide

生成物 1

HCID 203261583-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carbonitrile収率 95%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

Heat at its boiling point a mixture of 10 g of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxamide and 16.5 g of phosphorus oxychloride in 100 ml of 1,2-dichloroethane for 1 hour. Pour the resulting solution onto ice, and adjust the pH-value to 4 with saturated caustic soda solution. Separate the organic phase. Wash it with water and then evaporate it to dryness to obtain a 95% yield of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carbonitrile [m.p. 190° to 192° C].

後処理

  1. temperatureHeat at its boiling point
  2. additionPour the resulting solution onto ice
  3. customSeparate the organic phase
  4. washWash it with water
  5. customevaporate it to dryness

出典と根拠

ORDレコード
ord-02ce5c141d9f4185b794e6b791a8bd7b
出典データセット
uspto-grants-1978_06
特許番号
US04093812

関連ノート

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