Hydrochloric Acid → 5-Oxo-1-(4-sulfophenyl)pyrazolidine-3-carboxylic acid

HRID 839423ノート

反応式

HRID 839423 の反応式
[C:1]([O:8]C)(=[O:7])/[CH:2]=[CH:3]\[C:4]([O-])=[O:5].[NH:10]([C:12]1[CH:17]=[CH:16][C:15]([S:18]([O-:21])(=[O:20])=[O:19])=[CH:14][CH:13]=1)[NH2:11].C(=O)([O-])[O-].[Na+].[Na+].Cl>O>[C:1]([CH:2]1[CH2:3][C:4](=[O:5])[N:10]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([OH:21])(=[O:19])=[O:20])=[CH:14][CH:13]=2)[NH:11]1)([OH:8])=[O:7]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 10340Sodium Carbonate2 回HCID 1549500p-Hydrazinobenzene sulphonateHCID 21768182Mono-methyl maleate

生成物 1

HCID 203245745-Oxo-1-(4-sulfophenyl)pyrazolidine-3-carboxylic acid収率 89%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

50 parts of monomethyl maleate are added with stirring to 400 parts of water containing 70 parts of p-hydrazinobenzene sulphonate and 39 parts of sodium carbonate. The mixture is warmed until all reactants are in solution and the pH is adjusted by sodium carbonate to 9.2. The resulting solution is heated at 100° C for 9 hours. On completion of heating, the pH is adjusted to 3.8 by addition of hydrochloric acid and the 3-carboxy-1-(4'-sulphophenyl)-5-pyrazolidone thus formed is recovered and dried between 50°-100° C. The actual weight yield is 140 parts of strength 70% (determined by N.M.R.) which represents a yield of 89% of the theory.

後処理

  1. temperatureThe mixture is warmed until all reactants
  2. temperatureOn completion of heating

出典と根拠

ORDレコード
ord-45b863d13b1a4adda52f0d8bce9265c1
出典データセット
uspto-grants-1978_06
特許番号
US04095024

反応ノート

読み込み中…