Methyl iodide → 2-[Acetyl(2,2-diethoxyethyl)amino]-1-methylpyridin-1-ium iodide

HRID 839616ノート

反応式

HRID 839616 の反応式
[CH2:1]([O:3][CH:4]([O:16][CH2:17][CH3:18])[CH2:5][N:6]([C:13](=[O:15])[CH3:14])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH3:2].[CH3:19][I:20]>C(O)C>[I-:20].[CH3:19][N+:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[N:6]([C:13](=[O:15])[CH3:14])[CH2:5][CH:4]([O:16][CH2:17][CH3:18])[O:3][CH2:1][CH3:2]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 20323729HCID 20323729、化合物

生成物 1

HCID 203237172-[Acetyl(2,2-diethoxyethyl)amino]-1-methylpyridin-1-ium iodide収率 96%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

A mixture of N-acetyl-N-(2-pyridyl)-aminoacetaldehyde diethyl acetal (6.0 g.), methyl iodide (25 g.) and ethanol (30 ml.) was heated for 15 hours at 60° C in a sealed tube. The reaction mixture was concentrated and water was added to the residual oil. The mixture was washed twice with ether and the aqueous layer was concentrated under reduced pressure to give oil of 1-methyl-2-[N-acetyl-N-(2,2-diethoxyethyl)-amino]-pyridinium iodide (9.0 g.).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additionwater was added to the residual oil
  3. washThe mixture was washed twice with ether
  4. concentrationthe aqueous layer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-2e73f7b8b5a2407cbc17f05f6a155811
出典データセット
uspto-grants-1978_06
特許番号
US04096263

反応ノート

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