Chlorosulfonic acid → 2-(Methoxycarbonylamino) 6-(p-chlorosulfonylphenylthio) imidazo [1,2-a] pyridine

HRID 839628ノート

反応式

HRID 839628 の反応式
[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:10][N:9]2[CH:21]=1)=[O:4].[Cl:22][S:23](O)(=[O:25])=[O:24]>>[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:16]=[CH:17][C:18]([S:23]([Cl:22])(=[O:25])=[O:24])=[CH:19][CH:20]=3)=[CH:10][N:9]2[CH:21]=1)=[O:4]

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 12414300Methyl [6-(phenylsulfanyl)imidazo[1,2-a]pyridin-2-yl]carbamate

生成物 1

HCID 537731502-(Methoxycarbonylamino) 6-(p-chlorosulfonylphenylthio) imidazo [1,2-a] pyridine

実験手順

4.5 gms. (0.015 mole) of 2-methoxycarbonylamino 6-(phenylthio) imidazo [1,2-a] pyridine is added portionwise to 45 ml. of chlorosulfonic acid at 0° to -5° C. The reaction mixture is stirred at room temperature for 24 hours. The solution is poured onto ice and the solids are collected by filtration. After repeated washes with water, the crude chlorosulfonic acid derivative is dried at room temperature in vacuo.

後処理

  1. customat 0° to -5° C
  2. additionThe solution is poured onto ice
  3. filtrationthe solids are collected by filtration
  4. dry with materialthe crude chlorosulfonic acid derivative is dried at room temperature in vacuo

出典と根拠

ORDレコード
ord-6c8dbdfa11fb4c17956239422d7c5570
出典データセット
uspto-grants-1978_06
特許番号
US04096264

反応ノート

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