Hydroquinone → 4-(3-Bromopropoxy)phenol
反応式
[C:1]1([CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)[OH:2].[Br:9][CH2:10][CH2:11][CH2:12]Br.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:9][CH2:10][CH2:11][CH2:12][O:2][C:1]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1参加物
5
実験手順
A mixture of 88.0 g. (0.80 m.) of hydroquinone, 161.6 g. (0.80 m.) of 1,3-dibromopropane and 55.2 g. (0.40 m.) of potassium carbonate in 2 liters of 2-butanone was heated at reflux for 24 hours. The reaction mixture was filtered and the filtrate concentrated in vacuo. The solid and liquid phases of the residue were separated, and the liquid fraction was chromatographed on silica gel using chloroform-acetonitrile (95:5) as the eluant. There was thus obtained 37.2 g. of 4-(3-bromopropyloxy)phenol as a light brown oil which was used directly in the next reaction.
後処理
- additionA mixture of 88.0 g
- temperatureat reflux for 24 hours
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate concentrated in vacuo
- customThe solid and liquid phases of the residue were separated
- customthe liquid fraction was chromatographed on silica gel
- customof 4-(3-bromopropyloxy)phenol as a light brown oil which was used directly in the next reaction
出典と根拠
- ORDレコード
- ord-23bd87595a53454f8e2b7128ace45f69
- 出典データセット
- uspto-grants-1978_06
- 特許番号
- US04096280
反応ノート
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