2-(4-Methoxyphenyl)-2-methyl-5-benzyloxy-6,7-dichloro-1-indanone → 2-(4-Methoxyphenyl)-2-methyl-5-hydroxy-6,7-dichloro-1-indanone

HRID 839678ノート

反応式

HRID 839678 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH3:29])[CH2:17][C:16]3[C:11](=[C:12]([Cl:27])[C:13]([Cl:26])=[C:14]([O:18]CC4C=CC=CC=4)[CH:15]=3)[C:10]2=[O:28])=[CH:5][CH:4]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH3:29])[CH2:17][C:16]3[C:11](=[C:12]([Cl:27])[C:13]([Cl:26])=[C:14]([OH:18])[CH:15]=3)[C:10]2=[O:28])=[CH:5][CH:4]=1

参加物

4

反応物 1

HCID 124236152-(4-Methoxyphenyl)-2-methyl-5-benzyloxy-6,7-dichloro-1-indanone

生成物 1

HCID 124236162-(4-Methoxyphenyl)-2-methyl-5-hydroxy-6,7-dichloro-1-indanone

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

2-(4-Methoxyphenyl)-2-methyl-5-benzyloxy-6,7-dichloro-1-indanone (3.44 g., 0.008 mole) is catalytically hydrogenated in absolute ethanol (300 ml.) over 5% palladium on carbon (500 mg.) in a Parr apparatus at 25° C. for 4 hrs. The reaction mixture is filtered and concentrated in vacuo to give 2.6 g. of 2-(4-methoxyphenyl)-2-methyl-5-hydroxy-6,7-dichloro-1-indanone which melts at 149°-156° C. and is used without further purification.

後処理

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated in vacuo
  3. customto give 2.6 g
  4. customof 2-(4-methoxyphenyl)-2-methyl-5-hydroxy-6,7-dichloro-1-indanone which melts at 149°-156° C. and is used without further purification

出典と根拠

ORDレコード
ord-06a1ccc85da8409ba509b16a47133bd7
出典データセット
uspto-grants-1978_06
特許番号
US04096267

反応ノート

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