Urea → 1-(2-Ethylhexanoyl)urea

HRID 83976

反応式

HRID 83976 の反応式
[CH2:1]([CH:3]([CH2:7][CH2:8][CH2:9][CH3:10])[C:4](Cl)=[O:5])[CH3:2].[NH2:11][C:12]([NH2:14])=[O:13]>C(#N)C>[CH2:1]([CH:3]([CH2:7][CH2:8][CH2:9][CH3:10])[C:4]([NH:11][C:12]([NH2:14])=[O:13])=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 1176UreaHCID 791032-Ethylhexanoyl chloride

生成物 1

HCID 2252551-(2-Ethylhexanoyl)urea

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

2-Ethyl-hexanoylchloride (0.057 mol, Sigma-Aldrich Israel Ltd.), dissolved in dry acetonitrile (50 ml), was slowly added to a dry, boiling solution of urea (0.14 mole) in acetonitrile (100 ml) and allowed to reflux for 2 hours. Thereafter the organic solvent was evaporated under reduced pressure and the product was dissolved in ethyl acetate (100 ml) and washed three times with 20 ml of distilled water. The organic fraction was dried over MgSO4, filtered and evaporated under reduced pressure. The product was purified by crystallization from ethyl acetate.

後処理

  1. additionwas slowly added to a dry
  2. temperatureto reflux for 2 hours
  3. customThereafter the organic solvent was evaporated under reduced pressure
  4. dissolutionthe product was dissolved in ethyl acetate (100 ml)
  5. washwashed three times with 20 ml of distilled water
  6. dry with materialThe organic fraction was dried over MgSO4
  7. filtrationfiltered
  8. customevaporated under reduced pressure
  9. customThe product was purified by crystallization from ethyl acetate

出典と根拠

ORDレコード
ord-39f9ec2458c94c82a5b93820c547afd0
出典データセット
uspto-grants-2014_09
特許番号
US08846903B2

関連ノート

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