Ethylene Oxide → HCID 20322512、化合物

HRID 840005ノート

反応式

HRID 840005 の反応式
[CH2:1]([C:3]1([CH3:27])[NH:22][C:21]([CH2:24][CH3:25])([CH3:23])[CH2:20][C:5]2([NH:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:6]2=[O:19])[CH:4]1[CH3:26])[CH3:2].[CH2:28]1[O:30][CH2:29]1>CO.Cl>[CH2:1]([C:3]1([CH3:27])[N:22]([CH2:28][CH2:29][OH:30])[C:21]([CH2:24][CH3:25])([CH3:23])[CH2:20][C:5]2([NH:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:6]2=[O:19])[CH:4]1[CH3:26])[CH3:2]

参加物

5

反応物 2

HCID 6354Ethylene OxideHCID 20322535HCID 20322535、化合物2 回

生成物 1

HCID 20322512HCID 20322512、化合物収率 97.1%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid触媒HCID 887Methanol溶媒

反応条件

温度
110 °C

実験手順

To a solution of 6.0 g of 7,9-diethyl-6,7,9-trimethyl-3-octyl-1,3,8-triazaspiro[4.5]decane-2,4-dione (Compound 5) obtained as described in Example 4, in 40 ml of methanol were added 3 drops of concentrated hydrochloric acid and 3.5 g of ethylene oxide. The mixture was heated at 110° C for 24 hours in a sealed tube and then concentrated to give 6.5 g of Compound 118 as an oil. This product had an Rf value of 0.33 on thin layer chromatography on a 0.25 mm thick layer of silica gel (Kieselgel 60F 254, available from Merck & Co.; eluent, benzene containing 5% of triethylamine).

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-a3d84470103c40a1820caca10150dcb0
出典データセット
uspto-grants-1978_06
特許番号
US04097587

反応ノート

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