Sodium Iodide → 8-Iodo-1-octyne

HRID 840054

反応式

HRID 840054 の反応式
[CH2:1](OS(C1C=CC(C)=CC=1)(=O)=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]#[CH:8].[I-:20].[Na+]>CC(C)=O>[I:20][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]#[CH:8]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 10779145Oct-7-yn-1-yl 4-methylbenzene-1-sulfonate

生成物 1

HCID 226215568-Iodo-1-octyne収率 94.2%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 7-octynyl-p-toluenesulfonate (18.3 g, 65.2 mmol), sodium iodide (9.77 g, 65.2 mmol) and acetone (91 ml) was allowed to react for four hours under reflux. After cooling, the precipitates were removed by filtration, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (eluent; hexane) to afford 14.5 g of 8-iodo-1-octyne (yield; 94.2%).

後処理

  1. customto react for four hours
  2. temperatureunder reflux
  3. temperatureAfter cooling
  4. customthe precipitates were removed by filtration
  5. concentrationthe filtrate was concentrated
  6. customThe resulting residue was purified by silica gel column chromatography (eluent; hexane)

出典と根拠

ORDレコード
ord-15557948ec354671bcc50160cab9f5a5
出典データセット
uspto-grants-2002_04
特許番号
US06365350B1

関連ノート

読み込み中…