Sodium borohydride → 6-(1-Hydroxyprop-1-yl)-2-methyl-1,4-benzoxazin-3-(4h)-one
反応式
[C:1]([C:5]1[CH:6]=[CH:7][C:8]2[O:13][CH:12]([CH3:14])[C:11](=[O:15])[NH:10][C:9]=2[CH:16]=1)(=[O:4])[CH2:2][CH3:3].[BH4-].[Na+]>C(O)C.C1COCC1>[OH:4][CH:1]([C:5]1[CH:6]=[CH:7][C:8]2[O:13][CH:12]([CH3:14])[C:11](=[O:15])[NH:10][C:9]=2[CH:16]=1)[CH2:2][CH3:3]参加物
4
実験手順
6-(Propionyl)-2-methyl-1,4-benzoxazin-3-(4H)-one (1.1 g) is stirred with a half equivalent of sodium borohydride in 30 ml of ethanol/THF 1:1 for three hours at room temperature. The mixture is poured onto water, extracted with ethyl acetate, the organic phase is dried with magnesium sulfate and concentrated by evaporation. A yield of 95% results.
後処理
- additionThe mixture is poured onto water
- extractionextracted with ethyl acetate
- dry with materialthe organic phase is dried with magnesium sulfate
- concentrationconcentrated by evaporation
- customA yield of 95% results
出典と根拠
- ORDレコード
- ord-7c288a0a8602452099e043334a01f3dd
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06365736B1
反応ノート
読み込み中…