HCID 14330456、化合物 → 5-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

HRID 840433ノート

反応式

HRID 840433 の反応式
C(OC([NH:8][CH:9]1[CH2:14][C:13]2[C:15]([O:19][CH3:20])=[CH:16][CH:17]=[CH:18][C:12]=2[S:11][CH2:10]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[CH3:20][O:19][C:15]1[C:13]2[CH2:14][CH:9]([NH2:8])[CH2:10][S:11][C:12]=2[CH:18]=[CH:17][CH:16]=1

参加物

3

反応物 1

HCID 14330456HCID 14330456、化合物

生成物 1

HCID 143304585-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 10 g of N-t-butoxycarbonyl-3,4-dihydro-5-methoxy-2H-[1]-benzothiopyran-3-amine in 30 ml of trifluoroacetic acid is kept at room temperature for 1 hour. The solvent is removed in vacuo, the residue is treated with 1N NaOH and the product is extracted with ether. After drying over magnesium sulfate, the solvent is removed in vacuo to afford 3,4-dihydro-5-methoxy-2H-[1]-benzothiopyran-3-amine as an oil.

後処理

  1. customThe solvent is removed in vacuo
  2. additionthe residue is treated with 1N NaOH
  3. extractionthe product is extracted with ether
  4. dry with materialAfter drying over magnesium sulfate
  5. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-53d96b18d54b40e7b26ff77b9f118aa7
出典データセット
uspto-grants-2002_04
特許番号
US06368573B1

反応ノート

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