Methanol → 2-Bromoquinoline-4-carboxylic acid
反応式
[Br:1][C:2]1(C(OC)=O)[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.[OH-:16].[Na+].[CH3:18][OH:19]>O>[Br:1][C:2]1[CH:11]=[C:10]([C:18]([OH:19])=[O:16])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
A mixture of methyl 2-bromoquinolinecarboxylate (7.2 g) and NaOH (1.1 g) in 15 mL of methanol and 15 mL of water is stirred at 50° C. until TLC indicates the disappearance of starting material. After cooling, the methanol is evaporated and the mixture is treated with 28 mL of 1N HCl, the solid is collected by filtration and dried to afford 6.1 g of 2-bromoquinoline-4-carboxylic acid.
後処理
- temperatureAfter cooling
- customthe methanol is evaporated
- additionthe mixture is treated with 28 mL of 1N HCl
- filtrationthe solid is collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-cc693abf7f8b49c5b66ee0fb3e95f84e
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06369053B1
反応ノート
読み込み中…