Hydrogen Bromide → 1-Bromo-3,7-dimethyloctane

温度

100 °C

3,7-Dimethyloctan-1-ol (10.0 g, 63.2 mmol) was suspended in 48% aqueous hydrobromic acid solution, concentrated sulfuric acid (0.17 ml) was added dropwise and the mixture was stirred at 100° C. for 16 hr. The reaction mixture was allowed to cool to room temperature, extracted with hexane (200 ml), and washed twice with 5% aqueous sodium hydrogen carbonate solution (100 ml) and once with 20% brine (100 ml). The organic layer was dried over sodium sulfate, and the solvent in the filtrate was evaporated to give the title compound (13.3 g, 95.1%) as a colorless oil.

1. temperatureto cool to room temperature
2. extractionextracted with hexane (200 ml)
3. washwashed twice with 5% aqueous sodium hydrogen carbonate solution (100 ml) and once with 20% brine (100 ml)
4. dry with materialThe organic layer was dried over sodium sulfate
5. customthe solvent in the filtrate was evaporated

ORDレコード

ord-a59bb370680d405f82592bd4b5c44888

出典データセット

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08846885B2