Hydrogen Bromide → 1-Bromo-3,7-dimethyloctane

反応式

S(=O)(=O)(O)O.[CH3:6][CH:7]([CH2:11][CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[CH2:8][CH2:9]O.[BrH:17]>>[CH3:6][CH:7]([CH2:11][CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[CH2:8][CH2:9][Br:17]

参加物

反応物 3

HCID 260Hydrogen Bromide

HCID 1118Sulfuric Acid

HCID 77923,7-Dimethyl-1-octanol

生成物 1

HCID 1379141-Bromo-3,7-dimethyloctane収率 82.1%

実験手順

48% HBr (200 ml) and concentrated sulfuric acid (0.46 ml) were added to 3,7-dimethyl-1-octanol (21.0 g, 157.9 mmol), and the mixture was heated overnight. After allowing to cool to room temperature, and the mixture was extracted with hexane. The organic layer was washed with 5% aqueous sodium hydrogen carbonate solution and saturated brine, dried and concentrated to give the title compound (28.7 g, 82.1%).

後処理

temperaturethe mixture was heated overnight
extractionthe mixture was extracted with hexane
washThe organic layer was washed with 5% aqueous sodium hydrogen carbonate solution and saturated brine
customdried
concentrationconcentrated

出典と根拠

ORDレコード: ord-68ffd444f96c4333a3dda341ab53f8fc
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08846885B2

反応ノート

読み込み中…

参加物