5-Methoxy-3-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one → 3-(4-Aminophenyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one

HRID 840726ノート

反応式

HRID 840726 の反応式
[CH3:1][O:2][C:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)[N:4]=1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[N:4]=1

参加物

5

反応物 2

HCID 102361585-Methoxy-3-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 99207173-(4-Aminophenyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture consisting of 1.4 g of 5-methoxy-3-(4-nitrophenyl)-3H-(1,3,4)oxadiazol-2-one, 0.5 g of Pd/C and 20ml of methanol was hydrogenated under atmospheric pressure at room temperature until the calculated amount of hydrogen had been taken up. The catalyst was then filtered off, and the solution was concentrated in vacuo. The remaining semisolid residue was stirred with isopropanol and filtered off with suction.

後処理

  1. filtrationThe catalyst was then filtered off
  2. concentrationthe solution was concentrated in vacuo
  3. filtrationfiltered off with suction

出典と根拠

ORDレコード
ord-c9fe2b85bfef4974a91af7e163da366c
出典データセット
uspto-grants-2002_04
特許番号
US06369088B2

反応ノート

読み込み中…