Sodium Hydroxide → Sodium 2-bromo-5-methylbenzene-1-sulfinate

HRID 841114ノート

反応式

HRID 841114 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([OH:11])=[O:10].[OH-].[Na+:13]>CO.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([O-:11])=[O:10].[Na+:13]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 151553372-Bromo-5-methylbenzenesulfinic acid

生成物 1

HCID 23677276Sodium 2-bromo-5-methylbenzene-1-sulfinate

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

49.6 g of 2-bromo-5-methylbenzenesulfinic acid are dissolved in 400 ml of methanol and treated with an equimolar amount of NaOH in 50 ml of water. The mixture is stirred at RT for 3 hours, the solution is filtered off and subsequently the solvents are removed in vacuo. Finally, water residues are removed azeotropically with 50 ml of toluene. The solid residue is dried over P4O10 in vacuo and 54.0 g of product are obtained, mp 288-290° C. (with decomposition).

後処理

  1. filtrationthe solution is filtered off
  2. customsubsequently the solvents are removed in vacuo
  3. customFinally, water residues are removed azeotropically with 50 ml of toluene
  4. dry with materialThe solid residue is dried over P4O10 in vacuo and 54.0 g of product
  5. customare obtained

出典と根拠

ORDレコード
ord-a91ae303c4224422aa673b0a89744d80
出典データセット
uspto-grants-2002_04
特許番号
US06369236B1

反応ノート

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