化工社化工社 化学情報印刷レポート · 研究参考用
Lithium Hydroxide → 3-(3-Benzenesulfonyl-1H-indol-6-yl)-N-hydroxy-acrylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Diphenyl disulfide | HCID 13436 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 反応物 | PyBOP | HCID 2724699 | — |
| 反応物 | O-(Tetrahydropyran-2-yl)hydroxylamine | HCID 5142091 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 3-(3-Benzenesulfonyl-1H-indol-6-yl)-N-hydroxy-acrylamide | HCID 76035045 | — |
反応手順
Compound 24 was synthesized via the route as shown in Scheme 5 above (reagents and conditions: (a) Ph3P═CH—CO2CH3, CH2Cl2; (b) NaH, Ph-S—S-Ph, DMF; (c) MCPBA, CH2Cl2; (d) LiOH, MeOH, H2O; (e) (i) NH2OTHP, PyBOP, NEt3, DMF; (ii) TFA, MeOH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846748B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-bb26cdb93aed4d7085b435cf27d4bef9 |
| 出典メモ | uspto-grants-2014_09 |