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HRID84196

反应详情

EQUATION

反应方程式

HRID 84196 的结构方程式

REACTANTS

反应物

8
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：c1ccc(P(c2ccccc2)c2ccccc2)cc1
HCID11776

Triphenylphosphine

C18H15P

结构：c1ccc(SSc2ccccc2)cc1
HCID13436

Diphenyl disulfide

C12H10S2

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：O=C(OO)c1cccc(Cl)c1
HCID70297

Benzenecarboperoxoic acid, 3-chloro-

C7H5ClO3

结构：F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1
HCID2724699

PyBOP

C18H28F6N6OP2

结构：NOC1CCCCO1
HCID5142091

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

C5H11NO2

PRODUCTS

生成物

1
结构：O=C(C=Cc1ccc2c(S(=O)(=O)c3ccccc3)c[nH]c2c1)NO
HCID76035045

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

5
结构：CO
溶剂HCID887

Methanol

CH4O

2 次

结构：O
溶剂HCID962

Water

H2O

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

Compound 24 was synthesized via the route as shown in Scheme 5 above (reagents and conditions: (a) Ph3P═CH—CO2CH3, CH2Cl2; (b) NaH, Ph-S—S-Ph, DMF; (c) MCPBA, CH2Cl2; (d) LiOH, MeOH, H2O; (e) (i) NH2OTHP, PyBOP, NEt3, DMF; (ii) TFA, MeOH).