Sodium borohydride → 4-(4-Bromophenoxy)cyclohexanol
反応式
[BH4-].[Na+].[Br:3][C:4]1[CH:17]=[CH:16][C:7]([O:8][CH:9]2[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1>C(O)C>[Br:3][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH:9]2[CH2:10][CH2:11][CH:12]([OH:15])[CH2:13][CH2:14]2)=[CH:16][CH:17]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
Sodium borohydride (77.3 mg, 2.04 mmol) was added to a solution of 4-(4-bromophenoxy)cyclohexanone (500 mg, 1.86 mmol) in ethanol (10 mL) at room temperature. After 20 minutes the reaction was cooled to 0° C. and quenched by the addition of 1 N HCl (aq). The reaction was concentrated and the resulting residue was partitioned between ether and 1 N HCl (aq). The layers were separated, the organic layer was washed with water then dried (Na2SO4), filtered and concentrated.
後処理
- customquenched by the addition of 1 N HCl (aq)
- concentrationThe reaction was concentrated
- customthe resulting residue was partitioned between ether and 1 N HCl (aq)
- customThe layers were separated
- washthe organic layer was washed with water
- dry with materialthen dried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a6315e0a6ab34993b4d5a5d52a3f94b8
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846933B2
反応ノート
読み込み中…