Dichlorodimethylsilane → 4-(3,5-Dimethylphenyl)-2-isopropylindene

HRID 842505ノート

反応式

HRID 842505 の反応式
[Si](Cl)(Cl)(C)C.[CH3:6][C:7]1[CH:8]=[C:9]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[C:17]([CH:23]([CH3:25])[CH3:24])[CH-:18]3)[CH:10]=[C:11]([CH3:13])[CH:12]=1.[Li+]>C1COCC1>[CH3:13][C:11]1[CH:10]=[C:9]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[C:17]([CH:23]([CH3:25])[CH3:24])[CH2:18]3)[CH:8]=[C:7]([CH3:6])[CH:12]=1

参加物

4

反応物 2

HCID 6398DichlorodimethylsilaneHCID 22023013Lithium 4-(3,5-dimethylphenyl)-2-isopropylindenide

生成物 1

HCID 220230144-(3,5-Dimethylphenyl)-2-isopropylindene収率 72.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

SiMe2Cl2 (0.69 g, 5.4 mmol) was dissolved in 80 mL of THF. While stirring, lithium 4-(3′,5′-dimethylphenyl)-2-isopropylindenide (2.9 g, 11 mmol) was added as a dry powder and the contents allowed to stir overnight at room temperature. The solvent was removed in vacuo and the residue was taken up in pentane and filtered to removed LiCl salts. The pentane was removed in vacuo to yield a flaky white solid (2.1 g, 67%)

後処理

  1. stirringto stir overnight at room temperature
  2. customThe solvent was removed in vacuo
  3. filtrationfiltered
  4. customto removed LiCl salts
  5. customThe pentane was removed in vacuo

出典と根拠

ORDレコード
ord-48be1ea0c3a14500abc1b89882dddbb8
出典データセット
uspto-grants-2002_04
特許番号
US06376408B1

反応ノート

読み込み中…