Water → 3-Chloro-2-cyanopyrazine 1-oxide

HRID 842617

反応式

HRID 842617 の反応式
[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][CH:5]=[CH:4][N:3]=1.[OH2:10]>OS(O)(=O)=O>[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[N+:6]([O-:10])[CH:5]=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 962WaterHCID 2924653-Chloropyrazine-2-carbonitrile

生成物 1

HCID 107969923-Chloro-2-cyanopyrazine 1-oxide

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

2-Chloro-3-cyanopyrazine (5.00 g, 35.94 mmol) in concentrated H2SO4 (35 mL) at 0° C. was treated portionwise with K2S2O8 (11.65 g, 43.95 mmol), warmed to room temperature, stirred for 24 hours, treated with water, and extracted with chloroform. The organic extract was washed sequentially with water, saturated NaHCO3 and brine, dried (MgSO4) and concentrated to provide the title compound. MS (DCI/NH3) m/e 173 (M+NH4)+.

後処理

  1. extractionextracted with chloroform
  2. extractionThe organic extract
  3. washwas washed sequentially with water, saturated NaHCO3 and brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-aff5277d64c849fdb0f118686d72d8e9
出典データセット
uspto-grants-2002_04
特許番号
US06376488B1

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