Nitric Acid → HCID 22614896、化合物

HRID 842701ノート

反応式

HRID 842701 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[N:8]=[C:7]([O:13][CH3:14])[C:6]([O:15][CH3:16])=[N:5]2.[N+:17]([O-])([OH:19])=[O:18]>>[Cl:12][C:11]1[C:10]([N+:17]([O-:19])=[O:18])=[C:9]2[C:4](=[CH:3][C:2]=1[Cl:1])[N:5]=[C:6]([O:15][CH3:16])[C:7]([O:13][CH3:14])=[N:8]2

参加物

3

反応物 2

HCID 944Nitric AcidHCID 120471106,7-Dichloro-2,3-dimethoxyquinoxaline

生成物 1

HCID 22614896HCID 22614896、化合物収率 92%

反応条件

温度
10 °C

実験手順

6,7-Dichloro-2,3-dimethoxyquinoxaline (25 g, 0.096 mol) was added, portionwise, to fuming nitric acid (0.113 L) which had been pre-cooled to −5° C. The solution was allowed to warm to 10° C. and stirring continued for 2 hours. The solution was then poured into an ice/water mixture (0.5 L). The slurry was filtered and the solid was washed with water and isopropanol (0.05 L) to give 6,7-dichloro-2,3-dimethoxy-5-nitroquinoxaline(27 g, 92%) as a beige solid. m.p. 184-186° C.

後処理

  1. filtrationThe slurry was filtered
  2. washthe solid was washed with water and isopropanol (0.05 L)

出典と根拠

ORDレコード
ord-05f217c4140c4387bd8ccb75f92ac97a
出典データセット
uspto-grants-2002_04
特許番号
US06376490B1

反応ノート

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