Nitric Acid → 1,2-Dichloro-4-methyl-5-nitrobenzene
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH3:9])[CH:5]=[CH:6][C:7]=1[Cl:8].[N+:10]([O-])([OH:12])=[O:11]>O>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([N+:10]([O-:12])=[O:11])=[C:4]([CH3:9])[CH:3]=1参加物
4
実験手順
To stirred 3,4-dichloro-toluene 4 (10.0 g, 62.2 mmol) at 0° C. was slowly added fuming nitric acid (20.0 mL). The mixture was stirred for 2 hrs at RT, then water added (200 mL) and the reaction mixture filtered. The filtrate was purified by silica gel chromatography using 5% ethyl acetate in hexanes to give the title compound 11.7 g (92%). 1H NMR (400 MHz, CDCl3) δ8.14 (s, 1 H, Ar), 7.47 (s , 1 H, Ar), 2.59 (s, 3 H, CH3).
後処理
- filtrationthe reaction mixture filtered
- customThe filtrate was purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-a02dd13d827044d48b0a3fc2d4c19342
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06376530B1
反応ノート
読み込み中…