Isopropylamine → 2-Methylpropanoic acid (carboxymethylphosphonomethyl carbamoyloxy)-methyl ester-isopropylamine salt

HRID 843095ノート

反応式

HRID 843095 の反応式
[C:1]([CH2:4][O:5][P:6]([CH2:9][NH:10][C:11]([O:13][CH2:14][O:15][C:16](=[O:20])[CH:17]([CH3:19])[CH3:18])=[O:12])([OH:8])=[O:7])([OH:3])=[O:2].[CH:21]([NH2:24])([CH3:23])[CH3:22]>CC(C)=O>[CH:21]([NH2:24])([CH3:23])[CH3:22].[C:1]([CH2:4][O:5][P:6]([CH2:9][NH:10][C:11]([O:13][CH2:14][O:15][C:16](=[O:20])[CH:17]([CH3:18])[CH3:19])=[O:12])([OH:8])=[O:7])([OH:3])=[O:2]

参加物

4

反応物 2

HCID 6363IsopropylamineHCID 867579662-Methylpropanoic acid (carboxymethylphosphonomethylcarbamoyloxy)-methyl ester

生成物 1

HCID 867579682-Methylpropanoic acid (carboxymethylphosphonomethyl carbamoyloxy)-methyl ester-isopropylamine salt収率 90.8%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a stirred ice cold solution of 2-methylpropanoic acid (carboxymethylphosphonomethylcarbamoyloxy)-methyl ester (14.1 g, 43.8 mmol) in 80 mL of acetone was added isopropylamine (3.71 mL, 43.8 mmol). After 15 min of stirring the solvent was removed was removed under vacuum. The solid was washed with diethyl ether and subsequently dried under vacuum to afford 14.8 g of a tannish solid. 1H-NMR (300 MHz, D2O) δ (ppm): 1.01 (dd, 6H), 1.16 (d, 6H), 2.51 (m, 1H), 3.35 (m, 1H), 3.47 (d, 2H), 4.09 (d, 2H), 5.63 (d, 2H).

後処理

  1. customwas removed
  2. customwas removed under vacuum
  3. washThe solid was washed with diethyl ether
  4. customsubsequently dried under vacuum

出典と根拠

ORDレコード
ord-e55d0862b0784cba84138ed9f8ca2ffb
出典データセット
uspto-grants-2002_04
特許番号
US06376548B1

反応ノート

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