化工社化工社 化学情報印刷レポート · 研究参考用
Sulfuric Acid → Diacetone-D-glucose
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Alpha-D-Glucose | HCID 79025 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Diacetone-D-glucose | HCID 7067560 | 112.5% |
反応手順
Sulfuric acid (40 ml) is added dropwise to a solution of α-D-glucose (41) (50 g, 0,28 mol) in acetone (1 l) at 0° C. The reaction mixture is stirred for 24 h and then it is neutralized using sodium hydroxide (6 M). The acetone is evaporated and the aqueous layer is extracted with chloroform (X2). The chloroform is dried (MgSO4) filtered and evaporated. Crystallization from cyclohexane yielded the di-isopropylidene glucose (42) (41 g, 57%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06376657B1 |
| 出典データセット | uspto-grants-2002_04 |
| ORD ID | ord-80b91a09cd0a4ad6b1d6e94c624dd2c4 |
| 出典メモ | uspto-grants-2002_04 |