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HRID843209

反应详情

EQUATION

反应方程式

HRID 843209 的结构方程式

REACTANTS

反应物

3
结构：O=S(=O)(O)O
HCID1118

Sulfuric acid

H2O4S

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
HCID79025

alpha-D-Glucopyranose

C6H12O6

PRODUCTS

生成物

1
结构：CC1(C)O[C@H]2O[C@H]([C@H]3COC(C)(C)O3)[C@H](O)[C@H]2O1
HCID7067560

未命名化合物

收率 112.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Sulfuric acid (40 ml) is added dropwise to a solution of α-D-glucose (41) (50 g, 0,28 mol) in acetone (1 l) at 0° C. The reaction mixture is stirred for 24 h and then it is neutralized using sodium hydroxide (6 M). The acetone is evaporated and the aqueous layer is extracted with chloroform (X2). The chloroform is dried (MgSO4) filtered and evaporated. Crystallization from cyclohexane yielded the di-isopropylidene glucose (42) (41 g, 57%).

WORKUP

后处理

  1. customThe acetone is evaporated
  2. extractionthe aqueous layer is extracted with chloroform (X2)
  3. dry with materialThe chloroform is dried (MgSO4)
  4. filtrationfiltered
  5. customevaporated
  6. customCrystallization from cyclohexane