Phthalic Anhydride → 5-Phthalimido-1-pentanol

HRID 843249

反応式

HRID 843249 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][OH:7].[C:8]1(=O)[O:13][C:11](=[O:12])[C:10]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:9]12>C1(C)C=CC=CC=1>[C:8]1(=[O:13])[N:1]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][OH:7])[C:11](=[O:12])[C:10]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:9]12

参加物

4

反応物 2

HCID 6811Phthalic AnhydrideHCID 756345-Aminopentan-1-ol

生成物 1

HCID 5948445-Phthalimido-1-pentanol収率 74%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

10 g (96.9 mmol)of 5-amino-l-pentanol was dissolved in 300 ml of toluene and refluxed together with 17.2 g (116 mmol) of phthalic anhydride at 120° C. for 24 hours. The solvent was distilled off in vacuo, and the residue was purified by silica gel column chromatography (eluent; chloroform) to give 16.6 g of 5-phthalimido-1-pentanol in a yield of 74%.

後処理

  1. distillationThe solvent was distilled off in vacuo
  2. customthe residue was purified by silica gel column chromatography (eluent; chloroform)

出典と根拠

ORDレコード
ord-da90dd05946f41d2845ea21ea22426b3
出典データセット
uspto-grants-2002_04
特許番号
US06376671B1

関連ノート

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