Lithium Hydroxide → 2-(4-Benzyloxy-phenyl)-propionic acid

HRID 843392ノート

反応式

HRID 843392 の反応式
[CH3:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][CH:8]=1)[C:3]([O:5]C)=[O:4].[Li+].[OH-]>CO>[CH3:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4]

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 5255182-(4-Cyclohexylmethoxy-phenyl)-propionic acid, methyl ester

生成物 1

HCID 224649292-(4-Benzyloxy-phenyl)-propionic acid収率 90%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of methyl (R/S)-α-methyl-4-benzyloxyphenylacetate 45a (2.7 g, 10 mmol) in MeOH (25 mL) was added 1 N LiOH (15 mL). The mixture was stirred for 2 hour and concentrated. EtOAc was added followed by 1 N HCl (10 mL). The organic layer was separated and washed with brine, dried (MgSO4), and concentrated to afford the carboxylic acid (2.3 g, 90%) as a solid. MS (CI—NH3): (M+H+NH3)+=274.

後処理

  1. concentrationconcentrated
  2. additionEtOAc was added
  3. customThe organic layer was separated
  4. washwashed with brine
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-01b8ce23b9114614bd1ead03c8b73f53
出典データセット
uspto-grants-2002_04
特許番号
US06376665B1

反応ノート

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