Hydrochloric Acid → Methyl2-(2,3,4-trifluoroanilino)propionate

HRID 8434

反応式

HRID 8434 の反応式
[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:11]([O:16][CH3:17])(=[O:15])[C:12]([CH3:14])=O.Cl>CO.[Pd]>[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][CH:12]([CH3:14])[C:11]([O:16][CH3:17])=[O:15]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 11748Methyl pyruvateHCID 774682,3,4-Trifluoroaniline

生成物 1

HCID 22015876Methyl2-(2,3,4-trifluoroanilino)propionate収率 81.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

2,3,4-Trifluoroaniline (1.01 g) and methyl pyruvate (0.87 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g) and conc. hydrochloric acid (0.03 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa (converted from 30 kgf/cm2) for 2 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.31 g) was obtained as slightly yellowish crystals. Various spectral data of this product was identical with those obtained in Example 5.

後処理

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-4116153d24484c368b5531235418d367
出典データセット
uspto-grants-2006_08
特許番号
US07087778B2

関連ノート

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