Hydrochloric Acid → Ethyl 2-(2,3,4-trifluoroanilino)propionate

HRID 8435

反応式

HRID 8435 の反応式
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[N+:10]([O-])=O.[C:13]([O:18][CH2:19][CH3:20])(=[O:17])[C:14]([CH3:16])=O.Cl>C(O)C.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[NH:10][CH:14]([CH3:16])[C:13]([O:18][CH2:19][CH3:20])=[O:17]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 12041Ethyl pyruvateHCID 698711,2,3-Trifluoro-4-nitrobenzene

生成物 1

HCID 22015871Ethyl 2-(2,3,4-trifluoroanilino)propionate収率 97.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

2,3,4-Trifluoronitrobenzene (1.01 g) and ethyl pyruvate (1.15 g) were dissolved in ethanol (8 ml). After adding 5% Pd—C (0.11 g) and conc. hydrochloric acid (0.03 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.38 g) was obtained as slightly yellow oily substance. Various spectral data of this product was identical with those obtained in Example 7.

後処理

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-70f6d86b6a29466c9e871d6a54e57035
出典データセット
uspto-grants-2006_08
特許番号
US07087778B2

関連ノート

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