1-o-Benzyl-3-o-t-butyldimethylsilyl-2-o-methyl-rac-glycerol → 1-o-t-Butyldimethylsilyl-2-o-methyl-rac-glycerol

HRID 843568ノート

反応式

HRID 843568 の反応式
C([O:8][CH2:9][CH:10]([CH2:13][O:14][Si:15]([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16])[O:11][CH3:12])C1C=CC=CC=1>[Pd].CO>[Si:15]([O:14][CH2:13][CH:10]([CH2:9][OH:8])[O:11][CH3:12])([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16]

参加物

4

反応物 1

HCID 223164691-o-Benzyl-3-o-t-butyldimethylsilyl-2-o-methyl-rac-glycerol

生成物 1

HCID 223164511-o-t-Butyldimethylsilyl-2-o-methyl-rac-glycerol収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of the protected glycerol derivative 14 (5.0 g, 16 mmol) and 10% palladium on activated carbon (wet Degussa type E101 NE/W) (0.43 g) in MeOH (50 mL) was evacuated using an aspirator pump and filled with hydrogen. After 2 h, TLC analysis showed the reaction to be complete, the mixture was filtered through Celite and the filtrate was evaporated to dryness to give 1-O-t-butyldimethylsilyl-2-O-methyl-rac-glycerol (15) (99%) as a colourless oil.

後処理

  1. customwas evacuated
  2. additionfilled with hydrogen
  3. customthe reaction
  4. filtrationthe mixture was filtered through Celite
  5. customthe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-ba8d1dc08c7a47bf9954b20e010e118c
出典データセット
uspto-grants-2002_04
特許番号
US06380177B1

反応ノート

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