Sodium Carbonate → 5-(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)furan-2-carbaldehyde

HRID 84373

反応式

HRID 84373 の反応式
[F:1][C:2]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12](I)[S:13][C:6]=12.[CH:22]([C:24]1[O:28][C:27](B(O)O)=[CH:26][CH:25]=1)=[O:23].C([O-])([O-])=O.[Na+].[Na+]>COCCOC.C(O)C.O.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[F:1][C:2]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12]([C:27]3[O:28][C:24]([CH:22]=[O:23])=[CH:25][CH:26]=3)[S:13][C:6]=12

参加物

6

反応物 3

HCID 10340Sodium CarbonateHCID 27343555-Formylfuran-2-boronic acidHCID 594576617-(2-Fluoro-4-nitrophenoxy)-2-iodothieno[3,2-b]pyridine

生成物 1

HCID 866351855-(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)furan-2-carbaldehyde収率 84.2%

試薬・触媒・溶媒 2

HCID 178418476HCID 178418476、化合物触媒HCID 86587095Dimethoxyethane ethanol water溶媒

反応条件

温度
65 °C

実験手順

A stirred suspension of 7-(2-fluoro-4-nitrophenoxy)-2-iodothieno[3,2-b]pyridine (24) [US 2006/0287343 A1] (5.00 g, 12.01 mmol, scheme 4)], 5-formyl-2-furanboronic acid (2.19 g, 15.19 mmol), Pd(PPh3)2Cl2 (422 mg, 0.6 mmol), Na2CO3 (8.53 g, 80.50 mmol) in a mixture of DME/ethanol/water (60 mL/40 mL/40 mL) was degassed with nitrogen for 15 min, and heated at 65° C. for five hours under nitrogen. The reaction mixture was allowed to cool to room temperature, and filtered. The cake was successively washed with water and AcOEt. The filtrate and washings were combined, extracted with AcOEt. The extract was successively washed with water, saturated solution of ammonium chloride, water and brine, and concentrated. The residue was combined with the cake, absorbed on silica gel and subjected to flash column chromatography on silica gel (eluents AcOEt/DCM: 10/90 to 20/90, then MeOH/DCM: 5/95) followed by trituration with AcOEt, to afford aldehyde 107 (3.886 g, 84% yield) as a pale clay solid. MS (m/z): 385.0 (M+H).

後処理

  1. customwas degassed with nitrogen for 15 min
  2. temperatureto cool to room temperature
  3. filtrationfiltered
  4. washThe cake was successively washed with water and AcOEt
  5. extractionextracted with AcOEt
  6. washThe extract was successively washed with water, saturated solution of ammonium chloride, water and brine
  7. concentrationconcentrated
  8. customabsorbed on silica gel

出典と根拠

ORDレコード
ord-0d1e0d715cac49d39ed6c7ca02361e41
出典データセット
uspto-grants-2014_09
特許番号
US08846927B2

関連ノート

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