Ethyl isocyanate → HCID 22611366、化合物

HRID 843784ノート

反応式

HRID 843784 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH2:18]([N:20]=[C:21]=[O:22])[CH3:19]>C(Cl)(Cl)Cl>[CH2:18]([NH:20][C:21]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:22])[CH3:19]

参加物

4

反応物 2

HCID 8022Ethyl isocyanateHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

生成物 1

HCID 22611366HCID 22611366、化合物収率 82%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a solution of 15.0 mg (0.0655 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole in 3.0 mL chloroform were added 9.3 mg (0.131 mMol) ethyl isocyanate. The reaction was mixed for 48 hours and to it were then added 0.23 gm (0.131 mMol) aminomethylated polystyrene and the reaction mixed for an additional 18 hours. The reaction mixture was then filtered and the volatiles evaporated to give 16.1 mg (82%) of the title compound.

後処理

  1. additionThe reaction was mixed for 48 hours and to it
  2. additionwere then added 0.23 gm (0.131 mMol)
  3. additionthe reaction mixed for an additional 18 hours
  4. filtrationThe reaction mixture was then filtered
  5. customthe volatiles evaporated

出典と根拠

ORDレコード
ord-8bf8633d889a4f6f9f7249472d006d47
出典データセット
uspto-grants-2002_04
特許番号
US06380201B1

反応ノート

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