Dichloromethane → 1-Phenylimidazolidine-2-thione

HRID 84396

反応式

HRID 84396 の反応式
[C:1](N1C=CN=C1)(N1C=CN=C1)=[S:2].[C:13]1([NH:19][CH2:20][CH2:21][NH2:22])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(Cl)Cl>C1COCC1>[C:13]1([N:19]2[CH2:20][CH2:21][NH:22][C:1]2=[S:2])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 742701,2-Ethanediamine, N1-phenyl-HCID 802641,1'-Thiocarbonyldiimidazole

生成物 1

HCID 122691081-Phenylimidazolidine-2-thione収率 35.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1,1′-Thiocarbonyldiimidazole (4.51 g, 25.3 mmol) was added to a solution of N-phenylethylenediamine (3 mL, 23.02 mmol) in THF (230 mL) and the mixture was stirred for 2 h at room temperature. DCM was added and the solution was washed with 1N HCl, dried over anhydrous sodium sulfate and concentrated under reduced pressure affording title compound 301 (1.45 g, 8.13 mmol, 35.3% yield). m/z: 179.1 (M+H)+

後処理

  1. washthe solution was washed with 1N HCl
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-092dbad1ebed4eb6801116afed0aba82
出典データセット
uspto-grants-2014_09
特許番号
US08846927B2

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