N-bromobutanimide → HCID 22612209、化合物
反応式
[Cl:1][C:2]1[CH:6]=[C:5]([Cl:7])[S:4][C:3]=1[CH3:8].C1C(=O)N([Br:16])C(=O)C1>C(Cl)(Cl)(Cl)Cl.CCCCCC.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:16][CH2:8][C:3]1[S:4][C:5]([Cl:7])=[CH:6][C:2]=1[Cl:1]参加物
6
反応条件
- 温度
- 0 °C
実験手順
A solution of 3,5-Dichloro-2-methyl-thiophene (1.3 grams, 7.8 mmole), NBS (1.4 grams, 7.8 mmole) and benzoyl peroxide (0.065 g) in carbon tetrachloride (40 ml) was refluxed for 18 hours. The mixture was cooled to 0° C., diluted with 40 ml hexane and filtered. The filtrate was concentrated to an oil which was purified via flash chromatography on silica using hexane as eluent to give an oil (1.06 g). MW 245.95; MS (m/e) 246 (M++1).
後処理
- filtrationfiltered
- concentrationThe filtrate was concentrated to an oil which
- customwas purified via flash chromatography on silica
出典と根拠
- ORDレコード
- ord-bbdb5362085947d6a1a13b12be82f353
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06380218B1
反応ノート
読み込み中…