Sodium Hydroxide → 2,5-Dimethyl-3-furoic acid

HRID 844275

反応式

HRID 844275 の反応式
[CH3:1][C:2]1[O:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([O:9]CC)=[O:8].[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[O:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([OH:9])=[O:8]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 1414573-Furancarboxylic acid, 2,5-dimethyl-, ethyl ester

生成物 1

HCID 694652,5-Dimethyl-3-furoic acid収率 85.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3.2 g of ethyl 2,5-dimethylfuran-3-carboxylate, 35 ml of ethanol and 20 ml of 2 N sodium hydroxide was stirred at room temperature for 1.5 hours followed by heating under reflux for an hour. After the reaction mixture was allowed to cool to room temperature, it was concentrated under reduced pressure. The residue was dissolved in water and acidified with diluted sulfuric acid. Precipitated crystals were collected by filtration, washed with water and dried to give 2.27 g of 2,5-dimethylfuran-3-carboxylic acid in a 85% yield.

後処理

  1. temperatureby heating
  2. temperatureunder reflux for an hour
  3. temperatureto cool to room temperature
  4. concentrationit was concentrated under reduced pressure
  5. dissolutionThe residue was dissolved in water
  6. customPrecipitated crystals
  7. filtrationwere collected by filtration
  8. washwashed with water
  9. customdried

出典と根拠

ORDレコード
ord-e3a80f9624674176b0ed1b2286ce186f
出典データセット
uspto-grants-2002_04
特許番号
US06380247B2

関連ノート

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